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Hydration status significantly affects periorbital appearance with dehydration exaggerating dark circles through increased blood viscosity pooling more visibly, skin dullness from reduced cellular hydration making circles more prominent, and impaired lymphatic function allowing fluid retention despite overall dehydration

The non-motor symptoms appear before the onset of motor symptoms for many years

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485 The use of taurine deoxycholic acid, a BA derivative, improved ER stress and increased insulin sensitivity in the liver and muscle

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