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When classifying the SmGST family members, it was found that the cytoplasmic GST of the family includes Sigma classes besides the common Mu class, which found only in higher eukaryotes, but not in plants, insects and bacteria (36)

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Once synthesized, GSH serves as a substrate for GSH peroxidases (GPx), which reduce hydrogen peroxide and lipid peroxides into water and lipid alcohols, respectively (Lu, 2013)

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Although initial studies suggested that GSH depletion was only a byproduct of oxidative stress generated during cell death, recent discoveries suggest that GSH depletion and post-translational modifications of proteins through glutathionylation are critical regulators of apoptosis