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CGRP, when released from the bodies or axonal swellings of stimulated trigeminal neurons, can trigger satellite glial cells within the trigeminal ganglia, as well as microglia and astrocytes in the trigeminal nucleus caudalis

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This property is harnessed in PUVA therapy, where psoralens are administered orally, topically, or via bath solutions, followed by controlled exposure to UVA light, effectively slowing down the rapid proliferation of skin cells characteristic of these disorders

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Given the anticipated prevalence of depression and anxiety among cancer patients due to the detrimental effects of chemotherapy and the heightened severity observed in infertile women, MTZ pretreatment in cancer patients undergoing CP as an anti-cancer therapy would be beneficial in various respects (Altuner et al