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Following FOXO4 displacement, the released p53 undergoes nuclear export and mitochondrial translocation, activating the intrinsic apoptosis pathway via BAX upregulation and BCL-2 downregulation, culminating in caspase-3 cleavage and apoptotic cell death

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And critically for obesity research, it acts centrally: amylin binds to receptors in the area postrema and the brainstem, where it generates satiety signals that communicate to the brain that the body has had enough to eat

doi: 10.1038/s41429-025-00850-7 [DOI] [PubMed] [Google Scholar] 18.Teskey G, Cao R, Islamoglu H, et al