This amino acid is also used as the main oxidative fuel to replenish intermediates of the tricarboxylic acid cycle in rapidly dividing cells [1], such as enterocytes and colonocytes [6], fibroblasts, and immune cells such as lymphocytes [7, 8], macrophages, and neutrophils [9,10,11,12]
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Specifically, thiamine is important for glucose metabolism [51] and type 2 diabetics have been observed to have lower-than-average thiamine levels, suggesting that some degree of thiamine deficiency may play a role in the onset of diabetes
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Curr Mol Med (2022) 22(1):3749
Rotate sites daily around the abdomen, upper thigh or outer deltoid to prevent lipohypertrophy