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Dendritic Spine Formation and Neural Connectivity in Preclinical Models Dihexa has been evaluated in multiple preclinical models of cognitive impairment: Scopolamine-Induced Amnesia: Scopolamine blocks muscarinic acetylcholine receptors, producing temporary amnesia in rodents

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"Familial isolated pituitary adenomas (FIPA) and mutations in the aryl hydrocarbon receptor interacting protein (AIP) gene." Endocrinology and Metabolism Clinics of North America