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Nicotine is rapidly metabolized in vivo , with a t 1/2 of 12 h, 13 and smokers modulate their tobacco consumption to achieve a brain nicotine concentration that maintains the desired effects
[50] William Orzechowski and Robert Walker, The Tax Burden on Tobacco: Historical Compilation Volume 59, 2024 (Orzechowski & Walker, 2025), v
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