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Sometimes the synergy is structural

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In depression, while direct evidence linking NF-B and GPX4 remains limited, it has been established that both NF-B activation and GPX4 suppression contribute to brain injury, including neuronal loss, microglial overactivation, and reduced adult hippocampal neurogenesis (AHN) (Li et al., 2021

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However, this alone would support correlation and not causation and is a shortcoming of solely examining AD patient brain samples as evidence