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Overall, T cell activation leads to upregulation of the GSH pathway to prevent excessive ROS accumulation, ensuring the activation of mTOR and NFAT, and facilitating proper T cell metabolic reprogramming and cell fate decisions

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Hypertension 72 , 537548 (2018)

Tapered cessation maintains deep sleep architecture throughout the transition, while abrupt cessation often triggers 7-10 days of fragmented sleep as natural GH pulse timing (which peaks 60-90 minutes after sleep onset) struggles to re-establish

It directly scavenges ROS, including HO, superoxide anion, and nitric oxide, thus reducing oxidative damage 197,198