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When skin has lost its elasticity and you stretch it tight (remove all the excess skin), the skin once healed will continue to stretch out over time and become thinner and thinner

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Everything else is just plugging in numbers

The temperature should not exceed 40 degrees and the pH should be between 3-6

10.1523/JNEUROSCI.20-01-00034.2000 99 FeustelP

Importantly, there is very little direct experimental evidence in support of this hypothesis, which is based on the assumption that the neurotoxicity is caused by similar mechanisms as described for hepatotoxicity [183]