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The study also included a catalytically inactive C145A M pro mutant (lacking the active site cysteine), which was also used as a bait protein, in order to discriminate false positives that might bind non-specifically to the M pro active site cysteine via disulfide bond formation
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Combined application with other therapies: When combined with exercise, it can enhance the lipolysis induced by exercise and improve the efficiency of fat loss
Simvastatin, a semisynthetic lipophilic HMG-CoA reductase inhibitor, has demonstrated anti-fibroid properties by inhibiting fibroid cell proliferation, decreasing the expression of proliferative markers such as Ki67, and promoting apoptosis of fibroid cells (in a dose-dependent manner) in in vitro studies [81,83]
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