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Figures 4A, D) suggest that the mechanism of action of this compound involves, at least in part, decreased CBS activity through the NF-B and Akt/GSK3 pathways

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For example, a three-month course of lactulose therapy significantly improved sleep quality, reduced daytime sleepiness, and increased sleep duration and REM sleep in patients with minimal HE (31, 33)

However, there is evidence from DoD commercialization data to suggest that despite relatively flat DoD Research, Development, Test and Evaluation (RDT&E) funding through the 1990s, a steadily increasing number of DoD Phase II SBIRs won follow-on sales/investment contracts