In other diseases, inhibition of ACSL4 to reduce lipid peroxides and ferroptosis is a possible therapeutic strategy, but there is currently no similar study in preclinical studies of Friedreichs Ataxia
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In contrast, IRP2 knockdown or treatment with the ferroptosis inhibitor Fer-1 alleviates PC-12 cell damage by downregulating p53 levels and activating the SLC7A11-ALOX12 signaling pathway (Yao et al., 2024)
This proposed maximum at 110 would ensure that the application of the health equity adjustment allows for a hospital that receives the maximum number of points in weighted domain scores to still have the opportunity to receive the additional 10 HEA bonus points
10.1002/biof.1831 BioFactors
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