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Under normal conditions, TNF- signaling facilitates the recruitment of RIPK1 kinase to the plasma membrane, forming membrane-associated complex , which includes RIPK1, TRADD, TNF receptor-associated factor (TRAF), and cellular inhibitors of apoptosis proteins (cIAP1/2) (Holler et al., 2000)

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This reaction is severe and potentially life-threatening, including symptoms like unease, tingling, dizziness, itching, hives, swelling, difficulty breathing, and fainting

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According to the available scientific data, research experiments in rodents have lasted up to 45 days, with most studies ranging between 11-45 days or four weeks on average [3, 4, 7]