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Nonetheless, in very high doses, it can cause an intense acne flare-up

Pernicious AnemiaPernicious anemia is a blood disorder in which the body does not make enough red blood cells due to a lack of vitamin B12 in the blood

Combined NNMT inhibitor treatment with reduced-calorie diet achieved 6.3 g cumulative weight loss versus 2.9 g with diet alone, and fat mass reduction was ten-fold greater with treatment (~29.3%) compared to diet switch alone (2.9%), while restoring fatty liver profiles to lean-control levels (Sampson et al., 2021)

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Moderate protein intake (1.6-2.2 g/kg body weight) supports muscle preservation while in a deficit

Jack Spittler, a family medicine and orthopedics/sports medicine primary care specialist and orthopedic surgeon, and Dr