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Similarly, the expression levels of these proteins followed the same trend in co-cultured MCECs (Figures 6EH)

In line with this, a ROS/RNS-dependent regulation of IL-6 was envisaged in response to muscle exercise as shown by an impaired release of this cytokine after administration of vitamins A, C and E or inactivation of NOS by N()-nitro-l-arginine methyl ester (L-NAME) [110,111]

The mixture was sonicated twice for 5 min each time using a digital ultrasonic cleaner heated to 50 C

In vitro studies on human mononuclear cells also showed that alogliptin (0.5, 1 and 5 nM) treatment for 24 h exhibited a decrease in TLR-4 mediated increase in IL-1 and IL-6 [55]