Through chemical modification of the lysine side chain or backbone, molecules can be endowed with entirely new physicochemical properties and biological activities
doi: 10.3389/fmicb.2024.1446595 Received 10 June 2024 Accepted 02 August 2024 Published 14 August 2024 Volume 15 - 2024 Edited by Daniela De Biase, Sapienza University of Rome, Italy Reviewed by Wolfgang Buckel, University of Marburg, Germany Malte Sinn, University of Konstanz, Germany Updates Copyright 2024 Piskol, Lukat, Kaufhold, Heger, Blankenfeldt, Jahn and Moser
These variants do not cause ASD independently, but they increase vulnerability to environmental or metabolic stressors
TCF4 knockdown can promote ferroptosis and increase the cisplatin sensitivity of gastric cancer cells, 197 suggesting that abnormal activation of Wnt/-catenin pathway increases ferroptosis resistance in gastric cancer cells, offering a possible therapeutic strategy for enhancing chemotherapy sensitivity in patients with advanced gastric cancer
Over time, cells become less sensitive to this hormone and insulin resistance Leads to the potential development of Type 2 diabetes
These derivatives can then be further catalyzed by LPCAT3 to form PL-PUFAs, which participate in cellular membrane biosynthesis and are highly prone to peroxidation
