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However, growing evidence indicates that alternative metabolic routes such as malic enzyme 1 (ME1), isocitrate dehydrogenases (IDH1 and IDH2), and the folate cycle also significantly contribute to NADPH production, particularly under stress conditions or during metabolic reprogramming [43]

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As connective tissue is integral to bodily structure and function, the manifestations of such mutations can be wide, varied and sometimes life-threatening

The data also revealed lower blood glutathione levels in both Alzheimers disease and mild cognitive impairment, compared to healthy people