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Terra firma-forme dermatosis, or Duncan's dirty dermatosis, looks like acanthosis nigricans

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In fact, over the past couple of decades, aberrant intracellular ROS levels and the cell's inability to clear the oxidants have been implicated in various diseases, including cancer, neurodegenerative disease, cardiovascular disease, diabetes, and gastrointestinal disease (Box 2)

A suboptimal intake of the essential amino acids increases the bodys need for the non-essential amino acids either through diet or supplementation