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Krpereigenes Tri-Peptid (aus 3 Aminosuren)

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Oxidative stress: new insights on the association of non-alcoholic fatty liver disease and atherosclerosis

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(PubMed) Beedham C

FOXO4-DRI acts as a competitive inhibitor of this interaction binding directly to the transactivation domain 2 (TAD2) of p53, displacing FOXO4, and allowing phosphorylated p53 to be exported from the nucleus and directed to mitochondria, where it activates BAX, triggers caspase-3 cleavage (via the p53/BCL-2/Caspase-3 signalling pathway), and drives cell-intrinsic apoptosis