Small-molecule inhibitor characterisation
The lethal dose threshold (LD1) was never achieved in animal safety studies meaning researchers could not identify a dose lethal to 1% of test subjects
*Correspondence: Mathias Hallberg, [email protected] This article was submitted to Experimental Pharmacology and Drug Discovery, a section of the journal Frontiers in Pharmacology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers
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Allergic reactions to individual components are possible, though uncommon
A number of inhibitors have been developed: 78c has been demonstrated to restore tissue NAD + and ameliorate age-related metabolic dysfunction (Tarrag et al
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