2,3 Brain imaging has shown abnormalities in pain processing and reduced gray-matter volume in patients with fibromyalgia
The activation of insulin receptors on cells decreases the K ATP channel sensitivity to ATP inhibition and promotes the type A GABA receptors translocation, which lead to an increase in the efflux of K + and the influx of Cl , respectively, contributing to the hyperpolarization of -cell membrane and the resultant suppression of glucagon secretion 23,24,25
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