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9.1 Comparative mechanisms of action At the level of monoaminergic modulation, Rhodiola rosea demonstrates the most direct enhancement of serotonergic, dopaminergic, and noradrenergic neurotransmission, mediated in part through monoamine oxidase inhibition and presynaptic modulation of neurotransmitter availability (99)

As the membranes sustain oxidative damage, the mitochondria lose their ability to efficiently pump protons and generate ATP