Energy starts growing quietly before you feel it
Indeed, preclinical and clinical studies evidence beneficial effects of trimetazidine not only on mitochondrial energy metabolism but also on inflammation and oxidative stress compared to saline or vehicle [131, 132]
There is a notable lack of scientific literature exploring its potential effects on acute diabetic complications, such as diabetic ketoacidosis (DKA) or hyperosmolar hyperglycemic state (HHS)
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For this reason, they are recognized as a model system for investigating the effect of disease triggers such as hyperglycemia, oxidative stress, and hypoxia on the endothelium, as well as angiogenesis, and cellular immune responses mediated by leukocytes [83,84,85,86,87]