According to the protein misfolding avoidance hypothesis, natural selection disfavors the misfolding of highly expressed proteins, thereby constraining their evolution to minimize cytotoxicity 38
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Aron AT, Ramos-Torres KM, Cotruvo JA Jr, Chang CJ
Es un componente no esencial, que puede formarse a partir de dos aminocidos: la metionina y la lisina, ms la presencia de vitamina C, vitamina B3 (niacina), vitamina B6 (piridoxina) y hierro
This transient, noise-induced paradoxical phenomenon, which precedes the eventual silencing of auditory nerve fibers and synapses, may be characterized by (1) excessive glutamate release from IHCs, resulting in overactivation of receptors on auditory nerve fibers 66 , and (2) functional compensation by LOC efferent neurons, ensuring that auditory nerve activity is enhanced during periods of increased demand 67 , consistent with evidence suggesting that a primary function of LOC efferents is to reduce auditory neuropathy 68