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It has to be noted however that gain of function may also develop in parallel with loss of function, with reactive astrocytes for example losing their ability to clear glutamate in the context of motor neurone diseases

A exists in many forms, such as soluble, aggregated, oligomeric, protofibrillar, and fibrillar forms [2

This is most relevant at the thigh and abdomen in lean patients

Further randomized controlled trials are needed to verify the effect of gut microbiota on bone remodeling

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Similar results were found in an in vitro allergic mast cell model (93)