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doi: 10.1093/humupd/dmx016 159 ChenCZhouYHuCWangYYanZLiZet al

Benefits: Longer duration of action compared to cyanocobalamin May require less frequent dosing Preferred for patients with certain medical conditions Population-Specific Formulation Preferences The choice between cyanocobalamin and hydroxocobalamin depends on individual patient needs

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Mental illnesses including depression and seasonal affective disorder often correlate with suboptimal B12 levels , particularly during winter months when natural Vitamin D3 synthesis decreases

[DOI] [PubMed] [Google Scholar] Khoshakhlagh M, Butler AE, Jamialahmadi T, Sahebkar A