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Additionally, elevated levels of sphingomyelins, which promote neuroinflammation and apoptosis, have also been reported in AD patients [55]

392,393 Many of these substances induce widespread changes in astrocyte functions, including loss of functions and dysregulated astrogliosis, which in turn may serve as comorbidities in degenerative conditions such as AD, PD, and others

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Both pro-inflammatory and anti-inflammatory factors may have a causal link with asthma

It binds and unbinds in a constant exchange, so some free copper ions escape and irritate local nerve endings while activating mast cells (immune cells that release histamine and trigger inflammation)