cancer 116 (11), 13751381
Glutamate and schizophrenia: beyond the dopamine hypothesis
Glutathione (-glutamylcysteinylglycine) is a ubiquitous tripeptide thiol which plays a crucial role in oxidative stress defence mechanism of the cell
For instance, the bacterial metabolite Pseudomonas quinolone signal (PQS) activates host histidine methyltransferase carnosine-N-methyltransferase (CNMT), leading to epigenetic upregulation of transferrin receptor 1 (TFR1) and enhanced iron uptake, thereby promoting ferroptosis (Jia et al., 2025)
Use a Coffee Enema Another natural way to increase glutathione production is through the use of coffee enemas
However, both were sensitive to metal-induced oxidative stress, demonstrating the constraints of in vitro evaluations under biologically irrelevant conditions