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In the nucleus, following heterodimer complex formation with transcription factors, like small Maf proteins (G/F/K) and c-Jun, Nrf2 complexes bind to the antioxidant response element (ARE), a regulatory enhancer region within gene promoters that upregulate antioxidant and anti-inflammatory defense processes (Cuadrado et al., 2019

This is a significant finding for longevity-focused peptide research

In addition, it was found that the expression levels of Wnt4, 6, 7b, 10a, 10b, and 16 increased, and the -catenin pathway was hyperactivated in the hair follicles of EGFR-knockout mice

Updates log 26 May 2026: First publication

No head-to-head data exist