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The rupture of the physical barrier (OMM) that limits their release into the cytosol constitutes a point-of-no-return in cell death ( c release, whereas Bcl2-family death antagonists prevent it

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The full Thymosin Beta-4 molecule, under the name RGN-259, has entered formal clinical trials for conditions including dry eye disease and cardiac recovery, which validates the underlying biological mechanism that TB-500 shares