Cyanocobalamin : Synthetic form, requires conversion to active B12, longer shelf life, lower cost Methylcobalamin : Bioactive form, immediate utilization, preferred for neurological symptoms, more expensive Hydroxocobalamin: Used for cyanide poisoning, longest-acting Standard dose: 1000mcg/ml Routes: Deep IM (gluteal/deltoid) or subQ (abdominal) Loading phase: Daily/weekly for 1-4 weeks Maintenance: Monthly or every 3 months (hydroxocobalamin) No need for aspiration before injection Oral absorption requires intrinsic factor (absent in pernicious anemia) and healthy ileum
Evidence & regulatory status Evidence: substantial animal/preclinical literature
The NCAA, and virtually every other major sporting body, says no
Reduced Fat Storage: This peptide helps prevent the formation of new fat cells, supporting long-term weight management
You have a related condition: diagnoses such as pernicious anemia, malabsorption, celiac disease, or atrophic gastritis can establish medical necessity for injections
Step-down frameworks hold each lower dose for 8 to 12 weeks
