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10.1016/j.semcdb.2022.02.027 15 Husein el HadmedH.CastilloR

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(6), although there were no statistically significant differences between the UA group (1,000 mg/day) and the control group in peak oxygen uptake and performance on the 6-min walk test (6MWT), the UA group showed significant improvements compared to their own baseline

Bendell J, Blay J-Y, Cassier P, Bauer T, Terret C, Mueller C, et al

Moderate stage , where there is notable cartilage loss in weight bearing regions, along with meniscal degeneration, evidence of osteophytes and subchondral sclerosis, and weakening of the quadriceps muscles