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doi: 10.3389/fnut.2021.748075 Received 07 August 2021 Accepted 11 October 2021 Published 08 November 2021 Volume 8 - 2021 Edited by Clelia Madeddu, University of Cagliari, Italy Reviewed by Sidney B

Fasted-state dosing (minimum 3 hours post-meal) ensures low somatostatin tone and maximal pituitary responsiveness

The question of whether additional supplementation provides meaningful benefit on top of adequate dietary intake and normal endogenous production is exactly where the evidence gets thin

The peptides support cellular repair and reduce inflammation, while physical therapy provides the mechanical loading that drives nutrient diffusion into the disc and strengthens the muscular support system