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It is yet unclear whether central and peripheral symptoms are linked or develop independently of each other, hence a better understanding of their connections is important

However, natural products also present challenges such as structural complexity, poor stability, and limited bioavailability (Yao et al., 2017)

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Notably, DHLbut not lanosterolpotently activates liver X receptor alpha (LXR), suggesting that FOXO4 modulates cholesterol metabolism by enhancing DHL-mediated LXR signaling

Flag any metric that has drifted for two consecutive weeks and adjust before the drift compounds

Aging Cell 21 , e13646 (2022)