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and our targeted LCMS data demonstrate a profound change in broad metabolic activity in cells, supported by RNA-seq analysis of metabolic gene expression changes

A molecules effect depends not only on its intrinsic biology but on where it goes, how much of it reaches the target tissue, how long it persists, and what else it interacts with along the way

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Flow cytometry Intranuclear fluorescence staining and flow cytometry were used to determine histone acetylation levels in peripheral white blood cells