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6.4 Summary of RCTs In the RIPENACTB trial, adjunct NAC treatment with 1,200 mg twice a day in hospitalized HIV/TB patients significantly reduced circulating lipid peroxidation (malondialdehyde (MDA) levels by approximately 40%50%) and increased antioxidant defenses, including glutathione (GSH, by approximately 30%40%), compared to baseline and the standard care group

Finally, further significant efforts towards practical therapeutics led to FDA-approved ADCs: gemtuzumab ozogamicin (Mylotarg ) in 2000 for CD33-positive acute myelogenous leukemia (Sievers et al., 2001), brentuximab vedotin (Adcetris ) in 2011 for CD30-positive relapsed or refractory Hodgkins lymphoma and systemic anaplastic large cell lymphoma (Younes et al., 2010), and trastuzumab emtansine (Kadcyla ) in 2013 for HER2-positive breast cancer (LoRusso et al., 2011

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