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E7 binds and inactivates the retinoblastoma protein (pRb), releasing E2F transcription factors and driving uncontrolled cell-cycle progression

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Microglia, astrocytes, and infiltrating macrophages remain chronically activated and secrete neurotoxic factors, while dysfunctional oligodendrocytes and Schwann cells fail to uphold myelin and metabolic support

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Uncontrolled BT in Ghrl / mice was not due to a difference in energy intake