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It makes the research pointless

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LL-37 (5mg) LL-37 Peptide 5mg (Lyophilized Peptide in 3ml Vial) For Research Use Only LL-37 is a human antimicrobial peptide derived from the cathelicidin family, extensively studied for its roles in innate immunity, antimicrobial defense, wound healing, and inflammation regulation

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Because of the known association of claudin-2 with epithelial leakiness/permeability, increased claudin-2 expression has been suggested to promote mucosal inflammation