doi: 10.1093/nar/25.3.590 Veale, M
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In these selenoproteins, the Selenocysteine (Sec) residue is often observed at their enzymatic active site, which is critical for their function and activity (166)
Was shown to attenuate LPS-induced inflammation by inhibiting the release of pro-inflammatory cytokines (IL-6, TNF-) and mediators (iNOS, COX-2), decreasing ROS accumulation, and downregulating the expression of inflammatory genes in a tail transection-induced inflammation assay, thereby confirming its potent anti-inflammatory activity (Kim et al., 2020)
Readers should interpret the research summarized on this page as predominantly preclinical