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Pires, R.L

These findings could further substantiate a positive correlation and help identify common molecular targets for combating fungal pathogens along with the induction of tumor cell apoptosis

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To examine whether PlexinB1 activates the GTPase activity of Ran directly, purified cytoplasmic PlexinB1 protein of WT sequence (cytoPlexinB1-WT) or a mutant form of PlexinB1 with a non-functional GAP domain [23] (cytoPlexinB1-RA) were used in direct GTPase activating proteins (GAP) activity assays according to the method of Webb et al

Skin and Other Effects: Very rarely, severe skin rashes or abdominal pain have been reported