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However, the recovery of these regenerative capabilities (by increased expression of NAMPT for example) change the physiology of the cells towards stem-like cells, gaining some cancer properties, such as unlimited proliferative capacity, altered metabolism, DNA-repair, methylation alterations, with phenotype similar to CSCs, which deregulation by any other mutation initiate the tumor

Monitoring (extended protocols): IGF-1 is often monitored periodically during longer research protocols to confirm physiologic response and avoid excessive stimulation

The skin in those areas will start looking smoother and more even

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Rudin CM, Liu SV, Soo RA, Lu S, Hong MH, Lee JS, et al

Biotechnol J