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Although initially there were some doubts concerning this conclusion, mainly due to a lack of experimental support from animal studies and insufficient epidemiological evidence, but now numerous clinical experimental studies during the last decade have vindicated the IARC conclusion

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N., Howell, M

Vitamin Es direct neutralization of free radicals, especially when paired with CoQ10, offers a protective shield against lipid membrane peroxidative damage [84]

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10.1021/cr980139g 264 HochmairJ.ExnerC.BetzelC.MandelkowE.WegmannS