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interacts with glucose and metformin hydrochloride and alters their absorption kinetics after Coadministration in rats

Lagos-Quintana et al

PMID: 25857584

Simultaneously, ROS disrupts insulin signaling in peripheral tissues by promoting IRS-1 serine phosphorylation and degrading phosphatidylinositol-3-kinase (PI3K)/Akt activation, leading to insulin resistance (Papaetis et al., 2025)