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As well, mTORC2 is a rapamycin-insensitive complex that contributes to cell survival functions, metabolism, proliferation and actin polymerization

[DOI] [PubMed] [Google Scholar] Campbell S

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The authors established FOXO4-DRI as a first-in-class senolytic peptide tool for cellular senescence research, with mechanistic selectivity grounded in the elevated FOXO4-p53 interaction in senescent versus non-senescent cells