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5.6 CRISPR-Cas9 and genomic correction CRISPR-Cas9 enables precise genome editing and holds transformative potential for monogenic PD, particularly: Correction of LRRK2 G2019S , SNCA triplications, or PINK1 mutations

Its activity has been associated with reduced permeability disturbances and improved resistance to mucosal injury, particularly in models involving non-steroidal anti-inflammatory drug exposure (10)

Li and colleagues uncovered a compelling mechanism by which FASN contributes to sorafenib resistance in hepatocellular carcinoma (HCC): FASN binds to HIF-1, preventing its ubiquitination and degradation, thereby enhancing HIF-1s nuclear translocation and driving the transcriptional upregulation of SLC7A11an anti-ferroptosis gene

Aroor AR, Mandavia CH, Sowers JR

10.1371/journal.pone.0182558 114 LiuY.AoX.DingW.PonnusamyM.WuW.HaoX.et al (2018)