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Each bulk vial closure shall be penetrated only one time with a suitable sterile transfer device or dispensing set that allows measured dispensing of the contents

Answer: Patients often describe subtle changes in the first one to two weeks, more noticeable improvement between weeks two and six, and the most meaningful change by the end of an eight-to-twelve-week protocol

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As the deficiency is managed, the frequency can be reduced to weekly and then monthly for upkeep