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Further, MTX increased the expression of PERK (Figure 6B), GRP78 (Figure 6C), ATF4 (Figure 6D), and CHOP-10 (Figure 6E) in the liver compared to CTRL, indicating that ER stress is implicated in MTX-induced hepatotoxicity

( c ) Carnitine abundance (n = 8 technical replicates representative from 3 independent experiments)

OPG, 140.0 vs

Important Note: Supplements with high concentration in L-carnitine and no preservatives, may turn from powder form to solid form

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52,53 Additional examples of bioactive factors used in pre-clinical and clinical trials are included in Table 1, all of which suggest that tailored growth factor delivery may improve cartilage repair in aged patients