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Metformin and B12 One of the most clinically important causes of B12 depletion

B12 injections pair well with IV vitamin infusion therapy, pain management procedures, and neurological treatments

It is in this context that AOD 9604 is being mentioned more and more often a peptide that was originally studied in a completely different field but unexpectedly showed interesting effects for joints

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Be aware of this when reporting and interpreting laboratory results [see WARNINGS AND PRECAUTIONS ]

However, long-term NNMT inhibition in humans hasn't been characterized beyond small pilot cohorts, so concerns about sustained NAD+ elevation (which could theoretically promote certain cancers via PARP or SIRT activation) remain speculative but unresolved