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Although evidence is largely circumstantial or based on animal model studies, the preponderance of evidence weighs so heavily that a causal relationship can be inferred without remaining reasonable doubt [2]

paper introduced Dihexa as a metabolically stabilized AngIV analogue and reported reversal of scopolamine-induced spatial learning deficits in rats and improved spatial learning in aged rats following oral administration

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Stem cells have also shown significant benefits in neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), which is characterized by degeneration of upper and lower motor neurons, with mesenchymal stem cells possibly delaying progression of this disease and even giving partial recovery of neuron function [112-116]

In another example, a non-linear relationship indicates release of otic agent via a combination of diffusion and/or polymer gel degradation